Ah, the runics have higher damage, so we choose these right? No no. Lets take a better look at the damage difference between a Greater Talon and a Runic Talon: 
We have to following: 
  Both claws with a 350% ED Chaos runeword in them. 
  Level 30 Claw Mastery (151% ED) 
  120 Strength 
  120 Dexterity 
The formulae's to calculate a claw's damage (onscreen) are the following:

  Statbonus: ([Dexterity x 0.0075] + [Strength x 0.0075] + 1) 
  Minimal Damage: {((Statbonus) + (%Enhanced Damage/100)) x Mindmg on Weapon} 
  Maximal Damage: {(([Dex x 0.0075] + [Str x 0.0075] + 1) + (%Enhanced Damage)) x Maxdmg on Weapon} 
Lets start with the Greater Talon:

  Mindmg on Weapon: (21 * (3.5+1)) = 94,5 = 94 
  Maxdmg on Weapon: (35 * (3.5+1)) = 157,5 = 157 
  Statbonus: ([120 x 0.0075] + [120 x 0.0075] + 1) = 2.8 
  Minimal Damage: {((2.8) + (151/100)) x 94} = 405,14 = 405 
  Maximal Damage: {((2.8) + (151/100)) x 35} = 676,67 = 676 
So, this greater talon has a total damage of 405  676. That is an average of; (405+676)/2 = 540,5

Lets move on with a Runic Talon:

  Mindmg on Weapon: (24 * (3.5+1)) = 108 
  Maxdmg on Weapon: (44 * (3.5+1)) = 198 
  Statbonus: ([120 x 0.0075] + [120 x 0.0075] + 1) = 2.8 
  Minimal Damage: {((2.8) + (151/100)) x 108} = 465,48 = 465 
  Maximal Damage: {((2.8) + (151/100)) x 198} = 853,38 = 863 
This runic has a total damage of 465  863. That is an average of; (465+863)/2 = 664

Woah, so a runic has 123,5 more average damage?! Yes, too bad that is without the PvP penalty. After this penalty, the difference is only; (123,5*0,17) = 20,99 = 21. Add anoter 50% Damage reduction and we have a difference of only 10 damage.

The damage difference between greater talons and runic talons is pathetic, on top of that, a runic talon requires way more strength and dexterity. This means that a greater talon is superior to a runic because it gives you way more options of gear swapping while still staying at base strength/dexterity.
All in all: Use a greater talon, not a runic! (well, ok, unless you dont have any problemgiving gearswaps and you'll be able to use runics with base str/dex anyway)
